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In Muromachi Japan, an Emishi village is attacked by a demon. The last Emishi prince, Ashitaka, kills it before it reaches the village, but its corruption curses his right arm. The curse gives him superhuman strength, but will eventually spread and kill him. The demon was a boar god, Nago, corrupted by an iron ball lodged in his body. The village's wise woman tells Ashitaka that he may find a cure in the western lands Nago came from, but he cannot return to his homeland.Heading west, Ashitaka meets Jiko-bō, an opportunist posing as a monk, who tells Ashitaka he may find help from the Great Forest Spirit, a deer-like animal god by day and a giant Daidarabotchi by night. Nearby, men herd oxen to the town of Tataraba (Irontown), led by Lady Eboshi, and repel an attack by a wolf pack led by the wolf goddess Moro. Riding one of the wolves is San, a human girl. In Tataraba, Ashitaka learns that Eboshi built the town by clearcutting forests to claim ironsand and produce iron, leading to conflicts with the forest gods and Asano, a local daimyō. Tataraba is a refuge for social outcasts, including lepers employed to manufacture firearms; it was one of these guns that wounded Nago. Eboshi explains that San was raised by the wolves and resents humankind.San infiltrates Tataraba to kill Eboshi, but Ashitaka intervenes, revealing the curse to the townspeople, and knocks Eboshi and San out. He is shot by a villager but the curse gives him strength to carry San out of the village. San awakens and prepares to kill the weakened Ashitaka, but hesitates when he tells her that she is beautiful. She decides to trust him after the Forest Spirit saves his life. A boar clan, led by the blind god Okkoto, plans to attack Tataraba to save the forest. Eboshi sets out to kill the Forest Spirit with Jigo, who is working for the government; she intends to give the god's head to the Emperor in return for protection from Lord Asano. According to legend, the Forest Spirit's head grants immortality.Ashitaka recovers and finds Tataraba besieged by Asano's samurai. The boar clan is annihilated in battle, and Okkoto is corrupted by his wounds. Jiko-bō's men trick Okkoto into leading them to the Forest Spirit. San tries to stop Okkoto but is swept up in his demonic corruption. Ashitaka saves her and the Forest Spirit euthanizes Okkoto and Moro. As it transforms into the Daidarabotchi, Eboshi decapitates it. It bleeds ooze, which spreads over the land, killing anything it touches. Jiko-bō steals the Spirit's head. The forest and kodama begin to die; Moro's head comes alive and bites off Eboshi's right arm, but she survives.After Tataraba is evacuated, Ashitaka and San pursue Jiko-bō and retrieve the head, returning it to the Forest Spirit. The Spirit dies but its form washes over the land and heals it, and Ashitaka's curse is lifted. Ashitaka stays to help rebuild Tataraba, but promises San he will visit her in the forest. Eboshi vows to build a better town. The forest begins to regrow, and a kodama emerges from the undergrowth.

Gawl, Koji, and Ryo, three young scientists from the future, time travel to early 21st-century Japan to stop a terrible threat from undoing civilization. As they fight against time, their quest disrupts the lives of the townspeople, and the trio must use their incredible intelligence, along with Gawl's unique abilities, to protect their identities, their friends, and their future.

Ultimate L.A. slacker Jeff "The Dude" Lebowski, mistaken for a millionaire of the same name, seeks restitution for a rug ruined by debt collectors, enlisting his bowling buddies for help while trying to find the millionaire's missing wife